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International Journal of Pharmacology
Year: 2011  |  Volume: 7  |  Issue: 6  |  Page No.: 721 - 725

Observations on Chromosomal Aberrations Following the Administration of Methanol Sub-Fraction of Carica papaya Seeds for Contraception in Albino Rats and Rabbits

A.S. Ansari, S. Shrivastava, S. Goyal and N.K. Lohiya    

Abstract: The seed products of Carica papaya have been proven as potential male contraceptives in laboratory animals. In this study, chromosomal aberrations were investigated in spermatogonia of albino rats and rabbits, following oral administration of Methanol Sub-Fraction (MSF) of Carica papaya seeds. The experimental animals were divided into three groups, each group had 5 male Wistar rats and rabbits. In the first group, double distilled water served as negative control. The second group received monomeric acrylamide at 72.5 mg kg-1 body weight; two doses with a gap of 3 h served as positive control and in the third group, the MSF was orally administered at 500 mg kg-1 body weight (10 x contraceptive dose; CD); two doses with a gap of 3 h. The chromosomal fragments, dicentrics, rings, exchanges, damaged chromosomes and total chromosomal aberrations in MSF treated rats and rabbits were not significantly different when compared with negative control animals, however, were found to be reduced significantly (p<0.001) when compared with positive control group. The results suggested that the MSF did not induce chromosomal aberrations.

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