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International Journal of Pharmacology
Year: 2011  |  Volume: 7  |  Issue: 4  |  Page No.: 536 - 541

Screening of Berberis aristata DC. for Antimicrobial Potential against the Pathogens Causing Ear Infection

Chetan Sharma, K.R. Aneja and Ramkrashan Kasera    

Abstract: In the present study, the antimicrobial and minimum inhibitory concentration of B. aristata leaves and roots extracts were tested by agar well diffusion method against the six ear pathogens namely, Staphylococcus aureus, Proteus mirabilis, Escherchia coli, Pseudomonas aeruginosa, Acinetobacter sp. and Candida albicans. Root extracts displayed antimicrobial activity against all the tested ear pathogens, while leaf extracts showed activity against five tested ear pathogens. The highest antimicrobial activity of B. aristata root extract was found against S.aureus (28.3 mm) in acetonic extract with an MIC of 3.12 mg mL-1 and that of leaf also against S.aureus (27.6 mm) in hot aqueous extract with an MIC of 3.12 mg mL-1. Of the three organic extracts of B. aristata screened, the acetonic extra`ct showed the highest antimicrobial activity. This study suggests that the organic extracts of B. aristata showed broad spectrum antimicrobial activity and may be useful in treating ear infections.

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