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International Journal of Pharmacology

Year: 2011  |  Volume: 7  |  Issue: 3  |  Page No.: 410 - 414

Improvement of Pancreatic Langerhans Islets by Curcuminoid, S-Methyl Cysteine and Its Combination: An Immunohistochemistry Analysis

E. Sovia, E.Y. Sukandar, J.I. Sigit and L.D.N. Sasongko

Abstract

Turmeric and garlic have been known to have antibiabetes effect. Therefore, both can be used as an alternative therapy in the treatment of diabetes. However, their mechanism of action in lowering blood glucose is still unknown. In this study, we investigated the effect of curcuminoid, S-methyl cysteine and its combination on blood glucose level and improvement of pancreatic damage in alloxan induced diabetes mice. Curcuminoid, S-methyl cysteine and their combination were given for 21 days. Then, blood glucose levels were measured and mice were sacrificed and pancreas were isolated for immunohistochemical analysis. The results showed a significant difference of blood glucose levels between control group with treatment group. Adminstration of curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels significantly. Immunohistochemical analysis of pancreas showed a darker color intensity in the group given by curcuminoid and S-methyl cysteine compared with the control group. While the group given by its combination showed minor change compared with the control group. In conclusion curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels. Curcuminoid and S-methyl cysteine could repair damage of pancreas caused by the induction of alloxan while its combination showed only a minor improvement.

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