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International Journal of Pharmacology
Year: 2011  |  Volume: 7  |  Issue: 3  |  Page No.: 363 - 369

Anti-Diabetic Effects of Aqueous Ethanolic Extract of Hibiscus rosasinensis L. on Streptozotocin-Induced Diabetic Rats and the Possible Morphologic Changes in the Liver and Kidney

Rajesh Mandade and S.A. Sreenivas    

Abstract: Medicinal plants play a major role in the management of Diabetes mellitus especially in developing countries. The present study investigated the possible therapeutic effects of Hibiscus rosasinensis (H. rosasinensis) extract on certain biochemical markers in Streptozotocin (STZ)-induced diabetes mellitus in rats. The effects of an aqueous ethanolic extract of H. rosasinensis Aerial part on blood glucose, albumin, albumin/globulin ratio, urea, insulin, C-peptide, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Oral administration of H. rosasinensis (500 mg kg-1) aqueous extract to diabetic rats for 4 weeks significantly reduced blood glucose, urea, uric acid and creatinine but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. The present results shown that H. rosasinensis extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.

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