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International Journal of Pharmacology

Year: 2011  |  Volume: 7  |  Issue: 2  |  Page No.: 268 - 272

Synergistic Effect of Curcuminoid and S-methyl Cysteine in Regulation of Cholesterol Homeostasis

P. Hasimun, E.Y. Sukandar, I.K. Adnyana and D.H. Tjahjono


Turmeric and garlic have been known to lower cholesterol levels in hyperlipidemic state. Thus, both can be used as an alternative hyperlipidemia therapy to prevent complications of cardiovascular diseases. However, the mechanism of actions of both in lowering cholesterol are still unclear. The purpose of this study was to determine the effect of curcuminoid, S-methyl cysteine and its combination in regulation of cholesterol levels in serum, liver and feces. This study used an animal model of rats with cholesterol metabolism abnormality induced by propylthiouracyl for 7 days. Curcuminoid, S-methyl cysteine and its combination were given on day 8, 1 h before the induction of cholesterol solution. Total cholesterol level in serum, liver and feces were measured during 6 h of observation. The results showed that the curcuminoid, S-methyl cysteine and its combination maintained the serum cholesterol within the normal level by inhibiting cholesterol absorption and lowering cholesterol level in liver. Curcuminoid and its combination with S-methyl cysteine increased the conversion of cholesterol into the feces as much as 3 times higher than the control group. While the S-methyl cysteine alone did not increase the conversion of cholesterol into the feces. We concluded that curcuminoid and S-methyl cysteine have multiple site of actions in lowering cholesterol level in the body. Both also work synergistically to overcome hyperlipidemia.

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