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International Journal of Pharmacology

Year: 2011  |  Volume: 7  |  Issue: 2  |  Page No.: 180 - 188

A Systematic Review on the Relation between use of Statins and Osteoporosis

Pooneh Salari Sharif and Mohammad Abdollahi


The association between cardiovascular diseases and senile chronic diseases has been thought from many years ago. Osteoporosis is one of the major senile and chronic disease which accounts for high morbidity and mortality as well as high cost among elderly patients. Concerning the importance of prevention and treatment of cardiovascular disease as well as osteoporosis, and the pleiotropic effects of statins, the theory of the beneficial effects of statins on bone was proposed from different aspects such as the effect of statins on bone formation, bone resorption, bone mineral density and fracture risk. The probable link between cholesterol synthesis and bone metabolism has been also suggested. Regarding the link between cardiovascular disease and osteoporosis, in vitro studies show beneficial effects of statins on bone formation, however, most of clinical trials do not completely confirm the issue. Meanwhile, some investigators believe in the impact of statins on bone turnover. However, there is no conclusive data and agreement yet to recommend use of statins neither as a treatment nor prevention of osteoporosis. More longitudinal studies in different ethnicities with large sample sizes are suggested.

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