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International Journal of Pharmacology
Year: 2011  |  Volume: 7  |  Issue: 1  |  Page No.: 12 - 21

A Systematic Review on Oxidant/Antioxidant Imbalance in Aluminium Toxicity

Azadeh Mohammadirad and Mohammad Abdollahi    

Abstract: The purpose of this study was to provide a systematic review on the animal or human evidences linking aluminium (Al) toxicity to oxidant/antioxidant imbalance. Embase, Scopus, Pubmed, Web of Science, Google Scholar and SID databases were searched up to 1st October 2010. Over 50 studies including animal and human linking oxidative stress to Al were reviewed. Most of animal and human studies show a significant increase in lipid peroxidation (LPO) by Al. The maximum LPO was reported in the brain. Data about changes of enzymatic antioxidants such as Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) post exposure to Al are controversial. Animal studies showed that vitamin E, C, melatonin and pinoline reduce LPO in Al-exposed subjects. Al can affect body oxidant/antioxidant balance in favor of oxidative toxic stress. Among parameters tested in various studies, LPO seems the best indicator of Al toxicity. The role of iron homeostasis in mediation of cytotoxic effects of Al seems important. Since, oxidant/antioxidant imbalance is involved in the pathogenesis of many diseases including inflammatory bowel diseases, diabetes, osteoporosis, it would not be surprising to track roles of Al in many deliberating diseases in future.

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