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International Journal of Pharmacology
Year: 2010  |  Volume: 6  |  Issue: 5  |  Page No.: 624 - 630

Effect of Phyllanthus fraternus on Fructose Induced Insulin Resistance in Rats

A.S. Kushwah, B.M. Patil and B.S. Thippeswamy    

Abstract: Phyllanthus fraternus Webster (syn. Phyllanthus niruri) (PF) plant clinically used as a hepatoprotective, has been found to have wide range of biological activities. The purpose of this study is to examine the prophylactic effect of aqueous extract of (PF) on fructose induced-hyperinsulinemia, hypertriglyceridemia, glucose intolerance and hypertension in insulin resistance state in rats. Two groups of Male Sprague- Dawley rats fed either chow or fructose diets were treated with PF aqueous extract dose (250 mg kg-1 p.o.) or vehicle for three weeks in prophylactic treatment. Body weight changes, feed intake, water intake and blood pressure were recorded during experiment. After the completion of treatment period blood samples were collected for estimation of glucose, insulin and lipid profile and then animals were challenged for OGTT. Fructose feeding for three weeks significantly raised triglyceride levels (p<0.01), blood glucose (p<0.01), insulin levels (p<0.01), mean systolic blood pressure (p<0.001) and total aria under the curve (AUC) for glucose during OGTT (p<0.01) compared to chow fed rats. Treatment with PF (250 mg kg-1 p.o.) of fructose fed rats was found to significantly prevent hypertriglyceridemia (p<0.01), hyperglycemia (p<0.01), hyperinsulinemia (p<0.01), hypertension (p<0.01) and increase in total AUC (p<0.01) due to fructose feed. Aqueous extract of PF prevented the metabolic changes and hypertension induced by fructose diet in normal rats.

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