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International Journal of Pharmacology

Year: 2010  |  Volume: 6  |  Issue: 4  |  Page No.: 456 - 463

Clinical Study of Turmeric (Curcuma longa L.) and Garlic (Allium sativum L.) Extracts as Antihyperglycemic and Antihyperlipidemic Agent in Type-2 Diabetes-Dyslipidemia Patients

E.Y. Sukandar, H. Permana, I.K. Adnyana, J.I. Sigit, R.A. Ilyas, P. Hasimun and D. Mardiyah

Abstract

Turmeric (Curcuma longa L.) and garlic (Allium sativum Lin.) are known as traditional drugs that can cure several diseases such as dyslipidemia and diabetes. Many studies on individual usages of garlic and turmeric have been done previously. Present preclinical study showed that combination of both substances gave a better result compared to their individual usage. This research was aimed to evaluate the efficacy and safety of turmeric and garlic extracts combination as antihyperglycemic and antihyperlipidemic agents for type-2 diabetes-dyslipidemia. Three doses were evaluated: 1.2, 1.6 and 2.4 g, daily. It was found that the garlic-curcuma combination could reduce plasma glucose level and HbA1C as well as improve the lipid profile. Among those 3 dosages, the dose of 2.4 g decreased fasting glucose level, 2 h postprandial glucose level, HbA1C, total cholesterol, low density lipoprotein, triglyceride and body mass index more than the two other dosages. This dose level also increased high density lipoprotein higher than the other two dosages. There was no significant adverse event observed during the study. The treatment also showed no side effect on kidney and liver functions as well as the blood composition of all subjects.

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