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International Journal of Pharmacology
Year: 2010  |  Volume: 6  |  Issue: 3  |  Page No.: 264 - 270

Formulation of Microemulsion Systems for Improvement of Nitrofurazone Permeation Through Silicon Membrane as Burn Wound Imitating Coverage

B.S.M. Zadeh, H. Moghimi, P. Santos, J. Hadgraft, Majella E. Lane and F. Rahim    

Abstract: The basic objective of this study was to formulation of microemulsion for improvement of nitrofurazone permeation through silicon membrane and comparison between barrier properties of third-degree burned eschar and silicon as burn wound imitating coverage. Microemulsions were prepared with titration method and for evaluation the effect of parameter on barrier properties, three independent factors: proportion of surfactant/ co surfactant, percent of oil phase and Propylene Glycol (PG) as co surfactant were selected. The effect of independent variables on permeability parameters such as flux, D and Tlag were studied. Results showed, silicon performed less permeable membrane than eschar. The effects of microemulsion parameters on nitrofurazone permeability across silicon were not significant, but PG with effect on partitioning phenomena, increased flux and isopropyl myristate increased D.

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