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International Journal of Pharmacology
Year: 2009  |  Volume: 5  |  Issue: 6  |  Page No.: 381 - 383

Effect of Administration of Fungal Mycotoxin (Gliotoxin) on Clinical and Serobiochemical Parameters in Camels

M.S. Shathele    

Abstract: The main objective of this study was to determine the effect of administration of fungal mycotoxin (Gliotoxin) on clinical and serobiochemical parameters in camels. A bolus of 0.1 μg kg-1 b.wt. of gliotoxin was administered intravenously to camels. The treated camels were lethargic and decreased their appetite from day 3 onwards. The toxin administration decreased the protein and glucose concentration of serum. The increased activity of aspartate amino transferase, gamma glutamyl-transferase, sorbitol dehydrogenase and alkaline phosphatase due to mycotoxin administration was indicative of liver damage. High concentration of urea nitrogen and creatinine in treated animals was a characteristic of renal injury. In conclusion, the gliotoxin is acutely toxic to camels affecting liver and kidney function.

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