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International Journal of Pharmacology

Year: 2009  |  Volume: 5  |  Issue: 4  |  Page No.: 277 - 280

α-Glucosidase Inhibitor Activity of Terminalia Species

K. Anam, R.M. Widharna and D. Kusrini


Terminalia arjuna, Terminalia ballerica, Terminalia chebula, Terminalia catappa, Terminalia kaerbachii and Terminalia microcarpa leaves were tested for their α-glucosidase inhibitory activity in vitro. The α-glucosidase activity was determined by measuring the p-nitrophenol release from pNPG at 400 nm. Terminalia kaerbachii has the highest α-glucosidase inhibitor activity with IC50 value of 0.27±0.17 μg mL¯1 and is a promising antidiabetic herbal medicine candidate. However, most of the Terminalia species are also potential as antidiabetic medicine candidates as the IC50 values are approximately 5 μg mL-1, which is near the IC50 value of 1-deoxynojirimycin, the reference compound, except for Terminalia microcarpa, which has IC50 value of 25.15±0.04 μg mL-1 (above 21 μg mL-1). From the phytochemical screening, Terminalia kaerbacchi contains alkaloids, flavonoids and cathechic tannins, but does not contain saponin, quinon, steroid/terpenoids and gallic tannins. It is estimated that there is a correlation between α-glucosidase inhibitory activity and its phytochemical content.

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