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International Journal of Pharmacology
Year: 2008  |  Volume: 4  |  Issue: 1  |  Page No.: 56 - 59

A Coumarin from Ageratum Leaves (Ageratum conyzoides L.)

Gunawan Pamudji Widodo, Elin Yulinah Sukandar, Sukrasno and I. Ketut Adnyana    

Abstract: The aim of study was to isolate, characterize and elucidate of the antifungal compounds from acetone fraction of Ageratum leaves and to determine the antifungal activity of the isolated compounds. A coumarin compound has been isolated from acetone fraction of Ageratum leaves (Ageratum conyzoides L.) and chemical structure has been elucidated based on UV, IR, NMR and mass spectra. This compound showed an antifungal activity against the plant pathogenic fungi, Aspergillus niger. A. niger is a fungus and one of the most common species of the genus Aspergillus. It causes black mold on certain fruits and vegetables such as grape, onion and peanuts and is a common contaminant of food. The coumarin was tested for its antifungal activity against A. niger by disk diffusion method. The MIC values of coumarin was 62.5 μg mL-1.

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