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International Journal of Pharmacology
Year: 2007  |  Volume: 3  |  Issue: 6  |  Page No.: 510 - 514

On the Anti Oxidative Stress Potential of Zataria multiflora Boiss (Avishan shirazi) in Rats

Mona Babaie, Narguess Yasa, Azadeh Mohammadirad, Reza Khorasani and Mohammad Abdollahi    

Abstract: The present study was undertaken to explore the antioxidants effects of Zataria multiflora Boiss in rats. Antioxidant activity was measured by inhibition of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, Total Antioxidant Power (TAP) and Thiobarbituric Acid Reactive Substances (TBARS) in serum of treated rats. Rats received methanolic extract of Z. multiflora by intragastric intubation at doses of 50, 100 and 200 mg kg-1 daily for 14 consecutive days. The acute toxicity test (LD50) demonstrated that Z. multiflora is not lethal up to a dose of 2000 mg kg-1 after oral administration. Treatment of rats with Z. multiflora extract showed significant antioxidant activity in the DPPH test as compared to the control. Z. multiflora at doses of 50 and 100 mg kg-1 significantly increased TAP and decreased TBARS as compared to the control. Administration of Z. multiflora at a dose of 200 mg kg-1 per day did not significantly alter serum DPPH, TAP and TBARS. Antioxidant activities of Z. multiflora at doses of 50 and 100 mg kg-1 were in all experiments comparable to that of α-tocopherol. Further studies are needed to elucidate whether Z. multiflora as herbal medicine could be useful in the management of human diseases resulting from oxidative stress.

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