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International Journal of Pharmacology
Year: 2007  |  Volume: 3  |  Issue: 4  |  Page No.: 319 - 326

Effects of Diltiazem on Electrolytes Homeostasis in Streptozotocin-Induced Diabetic Rats

Najma Shaheen, Syed Muhammad Shahid and Tabassum Mahboob    

Abstract: Calcium concentration plays an important role in the development of diabetic complications in tissues permeable to glucose like liver, blood vessels of retina, kidney and central and peripheral nervous systems. This study was designed to investigate the possible involvement of intracellular electrolytes in antihypertensive effects of diltiazem in diabetes. In diltiazem treated control rats serum, heart, kidney calcium and magnesium were significantly decreased where as RBC, heart potassium and magnesium and Na-K-ATPase activity were significantly increased as compared to control animals. In STZ-induced diabetic rats serum sodium, magnesium, RBC potassium, ATPase activity, heart and kidney potassium were significantly decreased while serum potassium, glucose, RBC and heart sodium were significantly increased. In diltiazem treated diabetic rats serum and heart magnesium and serum glucose were increased where as RBC, heart, kidney sodium, heart, kidney calcium, kidney magnesium and kidney potassium were decreased significantly as compared to control rats. It is assumed that total peripheral resistance, systemic blood pressure and after load is decreased and thus diltiazem is useful in managing angina and hypertension in diabetes by decreasing calcium and sodium in heart and kidney tissues. Diltiazem may be useful in improving the clinical benefits for cardiovascular complications in diabetes.

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