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International Journal of Pharmacology
Year: 2007  |  Volume: 3  |  Issue: 2  |  Page No.: 155 - 159

Effect of Equisetum arvense L. (Equisetaceae) in Microalbuminuria and Creatinine Excretion in Streptozotocin-Induced Diabetes in Male Rats

Soleimani Safiyeh, Fathiazarbaijani Fathallah, Nejati Vahid, Shojaei Sadee Habib and Nanghshbandi Nabat    

Abstract: In the present research, the methanolic extract of Equisetum arvense was analysed for its antidiabetic activity in streptozotocin-induced diabetic rats. The efficacy of the extract was also evaluated for protection of renal defects in diabetic rats. The blood glucose lowering activity of the methanolic extract was determined in steptozotocin-induced (50 mg kg-1, i.p.; dissolved in normal saline) diabetic rats, after oral administration in doses of 50, 100, 250 and 500 mg kg-1 daily for 5 weeks. Urine samples were collected before the induction of diabetes and at the end of 5 weeks of treatments and analyzed for urinary microalbumin and creatinine level. The data was compare statistically using one-way ANOVA tukey test. The results showed that in different doses of methanolic extract blood sugar decreased significantly in comparison with the treatment and control groups of diabetic rats. Also the weights of methanolic-extract treatment group were higher than the other treatment groups. The present studies clearly indicate a significant antidiabetic and renoprotective effect with the methanolic extract of Equisetum arvense and lend support for its traditional usage.

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