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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 93 - 97

PTP1b: A Promising and Challenging Target for Metabolic Disease

Yan-ling Zhang, James F. Tobin and David V. Erbe    

Abstract: PTP1b is clearly involved in attenuating signaling by both insulin and leptin, prompting much effort towards the development of inhibitors of this enzyme as therapeutics to treat type 2 diabetes and obesity. In this mini-review, we discussed the physicochemical nature of the PTP1b active site and how this poses challenges for drug design.

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