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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 6  |  Page No.: 674 - 677

In vitro Antibacterial Screening of Anethum graveolens L. Fruit, Cichorium intybus L. Leaf, Plantago ovata L. Seed Husk and Polygonum viviparum L.Root Extracts Against Helibacter pylori

Rifat-uz-Zaman, Muhammad Shoaib Akhtar and Muhammad Shafiq Khan    

Abstract: In the present study, extracts from four folkloric medicinal plants, previously reported potential anti-ulcer; Anethum graveolens L. fruit, (AG), Cichorium intybus L. leaf, (CI), Plantago ovata L. seed husk (PO) and Polygonum viviparum, L. root, (PV), were screened for anti-Helicobacter pylori (HP) activity. Anti-HP activity of the powdered drugs extracted by water, ethanol, ethyl acetate and acetone, obtaining yields of 2.34-13.43 g kg-1 (w/w), by using the turbidity method was determined. The aqueous extract exhibited the lowest minimum inhibitory concentrations (MICs) against H. pylori strain (obtained from ulcer patients), of which ranged from 0.6 to 10.5 mg mL-1, followed, in ascending order, by the Cichorium intybus leaf (CI), Polygonum viviparum root (PV), Anethum graveolens fruit (AG) and Plantago ovata seed husk (PO). Antibacterial activity was determined CI, PV, PO, AG extracts, with the highest percentage of inhibition (1.2-62.6%) demonstrated for the water, followed, in descending order, by the ethanol, ethylacetate and acetone analogs. Anti-HP activity appeared to be in a dose-dependent manner. The extracts (aqueous and ethanol) of CI and PV due to potent and AG and PO due to the moderate potent anti-H. pylori activities might ultimately be proved, the preferred and curative anti-ulcer agent.

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