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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 60 - 65

Effect of Dietary Supplementation of Ellataria cardamomum and Nigella sativa on the Toxicity of Rancid Corn Oil in Rats

Abdulaziz M. Al-Othman, Fasih Ahmad, Saada Al-Orf, Khalid S. Al-Murshed and Zarina Arif    

Abstract: In the present study Nigella sativa and Ellataria cardamomum seeds have been studied as inhibitors of oxidative stress caused by oxidized corn oil (having PV 389.8 meq kg-1) in rats. The 70 days feeding male albino rats with experimental diets did not produce significant changes in the body weights, organ weights and food intake of different groups. Increased lipooxidative damage was noticed in oxidized oil fed rats. Oxidized oil diet supplemented with cardamom or N. sativa had marked reduction in RBC hemolysis and plasma AST/ALT activity. The formation of thiobarbituric acid reactive substances were lowest in rats fed N. sativa supplemented diet. Reduced glutathione of liver and kidney were significantly raised after the addition of cardamom/N. sativa to the diets compared to oxidized oil fed rats (Group F). But heart reduced glutathione showed a significant increase as compared to oxidized oil fed group only after the supplementation of N. sativa to the diet. These data indicates that N. sativa or cardamom supplementation improves the overall antioxidant protection capacity of the body.

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