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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 5 - 8

Chloroquine and Folic Acid Interactions in Respiration Induced Oxidative Stress

H.O.T. Iyawe and A.O. Onigbinde    

Abstract: This study was designed to access the interaction between chloroquine and folic acid in respiration induced oxidative stress, with the aims of employing these drugs in the treatment of malaria infection in the tropical and subtropical regions where the disease is endemic. A total of forty mice comprising of twenty males and twenty females were used in this investigation. Each sex category was divided into four groups of five mice and designated control, chloroquine, folate and chloroquine-folate group, respectively. All drugs were administered intraperitoneally (ip). Data collected and analyzed from treated mice show that folic acid reduced (p<0.05) malondialdehyde concentration in male and female mice. All administered drugs increased (p<0.05) the activities of Superoxide Dismutase (SOD) in male and female mice compared to the control groups. Catalase activities increased (p<0.05) in females treated with chloroquine and the female group that received combined dose and in chloroquine treated males. Significant differences (p<0.05) were recorded in the activities of Aspartate Aminotransferase (AST) and Gamma Glutamyl Transferase (GGT) activities in male and female mice. The finding from this study shows folic acid as having antioxidant property and chloroquine as a suppressant of this antioxidant activity of folic acid in normal mice.

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