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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 4  |  Page No.: 467 - 470

Evaluation of Long-Term Usage of Low Dose Doxycycline after Periodontal Surgery in Patients with Chronic Periodontitis

N. Sargolzaei, H.R. Arab, A. Moeintaghavi, H. Ghanbari, A. Rigi and M. Hosseini Hoshyar    

Abstract: The major aim of periodontal treatment is reconstruction of broken tissues and maintenance of periodontal health. Different chemotherapeutic agents are used to change the host response to bacterial irritants along with nonsurgical and surgical periodontal therapies. Doxycycline is one of these agents used widely due to its anticollagenolytic and antibacterial properties. The aim of this study was to evaluate the effect of long-term usage of low dose doxycycline after periodontal surgery in the treatment of chronic periodontitis. In this study, 30 patients with chronic periodontitis were selected. After initial therapy and periodontal surgery, all patients were recalled and Probing Depth (PD), Attachment Level (AL) and Bleeding on Probing (BOP) indices were measured. Then they randomly allocated to test and control groups. In the test group (15 patients) all patients received 90 capsules (20 mg doxycycline) to use one cap per day for the following 3 month. The controls received the same shape and color placebo capsules. All the patients were recalled after one and 3 month and the above mentioned parameters were recorded again. The results showed significant reduction in PD and AL in the test group. Bop did not change significantly in both groups. PD and CAL increased in the control group but these increases were significant only for PD. The results of this study showed that the use of low dose doxycycline along with supportive periodontal treatment and oral hygiene during maintenance period can improve the clinical parameters.

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