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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 45 - 49

Aqueous Extracts of Andographis paniculata Improve Lipid Profiles of Rats Fed with High Cholesterol Diet

A. Zuraini, M.R. Ros Aziah, A.K. Arifah, M.R. Sulaiman and M.N. Somchit    

Abstract: The aim of present study was to investigate the potential roles of aqueous extracts of A. paniculate in lowering the plasama lipid parameter which is responsible for hyperlipidemia and its damaging consequences and also to determine the kidney and liver functions of rats. Plasma Total Cholesterol (TC), Low Density Lipoproteins (LDL) cholesterol and Triglycerides (TG) had progressively increased in cholesterol-fed rats up to 4 weeks of cholesterol-feeding. Both 100 and 200 mg kg 1 concentrations of A. paniculata extracts had kept TC, LDL and TG values within the normal range even after 4 weeks of feeding. No significant enhancement was found in the amount of High Density Lipoproteins (HDL) cholesterol and the kidney and liver enzymes of the rats, i.e. Blood Urea Nitrogen (BUN), total creatinine and Lactate Dehydrogenase (LDH) and Aspartate Amino Transferase (AST) and Alanine Aminotransferase (ALT), respectively indicating normal kidney and liver functions. From the current study, it can be concluded that 100 and 200  mg kg 1 aqueous extract of A. paniculata appeared to possess great potentials as anti-hyperlipidemic agent in rats.

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