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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 4  |  Page No.: 435 - 438

Anti-inflammatory, Analgesic and Antipyretic Activities of Dicliptera verticillata

Wamtinga Richard Sawadogo, Rainatou Boly, Marius Lompo, Noya Some, Charles Euloge Lamien, Innocent Pierre Guissou and Odile Germaine Nacoulma    

Abstract: The methanol extract of Dicliptera verticillata stems with leaves was investigated for its anti-inflammatory, analgesic and antipyretic activities in animal models. The extract was found to reduce significantly (p<0.001) the formation of oedema induced by carrageenan after 3 h. In the acetic acid induced writhing model, the extract has shown a good analgesic effect characterised by a significant reduction (p<0.001) in the number of writhes with all the doses used when compared to the control untreated group. In the antipyretic assay, the extract was efficient on yeast-induced hyperpyrexia in mice, mainly 2 h after drugs administration. The results give a scientific basis to the traditional uses of Dicliptera verticillata, mainly those involving pain, fever and inflammation.

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