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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 4  |  Page No.: 421 - 425

Acute and Subchronic (28-day) Oral Toxicity Studies of the Aqueous Root Extract of Securidaca longepedunculata Fresen (Polygalaceae) in Mice

E.U. Etuk, R.A. Adebiyi, A.T. Elsa and B.M. Agaie    

Abstract: The acute and subchronic (repeat dose) oral toxicity of aqueous root extract of Securidaca longepedunculata was evaluated in mice. In the acute toxicity test, oral administration of limit dose of 5 g kg-1 of the extract produced neither mortality nor any acute signs of toxicity throughout the 14 days period of observation. In the subchronic toxicity study, there was no mortality recorded among the animals when varying doses of the extract (300, 900 and 2700 mg kg-1 body weight) were administered orally for 28 days consecutively. The weekly body and organ weights of the mice showed no significant differences between the control and the mice treated with the extract except on the last week (day 28) where there was significant increase (p<0.05) in the body weight of mice treated with 2,700 mg kg-1 of the extract. In the haematological analysis, there were significant (p<0.05) decrease in the Red Blood Cell (RBC) count at 2700 mg kg-1 and in Packed Cell Volume (PCV) of mice treated with 300 and 2,700 mg kg-1 of the extract, while the differential leucocytes count showed no differences in any of the parameter examined. Also, there was no significant changes in the biochemical parameters tested. There was neither any gross lesion nor histopathological changes observed in the organs (liver, kidney and brain) examined. These findings suggest that the aqueous root extract of S. longepedunculata could be relatively safe when administered orally in mice.

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