Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 3  |  Page No.: 320 - 323

The Effect of Sulphamethazine Combination on the Plasma Kinetics of Chloramphenicol in Sokoto Red Goats

E.U. Etuk, P.A. Onyeyili and S.O. Bello    

Abstract: A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by chemical assay method and its combination with sulphamethazine (33 mg kg-1) in Sokoto red goats has revealed that the mean peak plasma concentrations at 0.08 h post drug administration were not significantly different. However, various pharmacokinetic parameters were significantly altered (p<0.05) after the combination therapy; the total body clearance (Cl) and elimination constant (β) were significantly higher whereas the half life of elimination (t½ β) and the distribution rate constant were significantly lower. These changes observed in this study could be an indication that, the combination therapy may require a reduced chloramphenicol dose without necessarily minimising the efficiency of the drug and this may also possibly reduce the risk of dose-related toxicity.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility