Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 28 - 32

The Effect of Salmonella infection on the Plasma Kinetics of Chloramphenicol in the Sokoto Red Goats

E.U. Etuk and P.A. Onyeyili    

Abstract: This study was to determine the effect of salmonella typhimurium infection on the plasma kinetic profile of chloramphenicol in the locally breed goats of Sokoto state, Nortwestern Nigeria. Chloramphenicol administered intravenously at the dose of 25 mg kg-1 body weight to healthy and salmonella typhimurium infected goats; assayed chemically and pharmacokinetic parameters assessed by use of two compartment open model has shown significant changes in the kinetic profile of the drug after the infection. The mean plasma concentrations of the drug were lower in the inoculated goats. The volume of distribution (Vdβ), total body clearance (Cl) and elimination constant (β) were significantly higher while the distribution half life (t½α), elimination half life (t½β) and the Area Under the Curve (AUC) were significantly reduced after the infection. Salmonella typhimurium infection has altered the distribution of chloramphenicol, increased the loss of the drug and reduced its mean residence time in the body of the goats.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility