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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 2  |  Page No.: 209 - 212

Comparison of Antinociceptive Effects of Total, Water, Ethyl Acetate, Ether and n-butanol Extracts of Phlomis anisodonta Boiss. and Indomethacin in Mice

Naghmeh Hajarolasvadi, Mohammad J. Zamani,, Parisa Sarkhail, Reza Khorasani, Masoomeh Mohajer, Gholamreza Amin, Abbas Shafiee, Mohammad Sharifzadeh and Mohammad Abdollahi    

Abstract: The objective of the present study was to evaluate the anti-inflammatory and analgesic activities of the crude and fractioned extracts (ether, ethyl acetate, n-butanol and water) of Phlomis anisodonta (Lamiaceae) in the models of carrageenan-induced paw edema and acetic acid-induced writhing in mice. Dried powdered material from the aerial parts of Phlomis anisodonta was extracted with methanol (80%) twice. The methanol extract was separated into four fractions: after drying the methanol extract, the solid residue was dissolved in water and the water-soluble portion was successively partitioned to produce the above-mentioned fractions. The total extract, ether fraction and ethyl acetate fractions significantly reduced the number of writhings compared to the control group. Water and n-butanol fractions showed no analgesic activity. Neither the total extract nor four fractions were more effective than indomethacin in acetic acid-induced test. In carrageenan-induced inflammation test, only water and ethyl acetate fractions showed antiinflammatory activity compared to the control group. The total extract, n-butanol and ether fractions showed no antiinflammatory activity. Neither the total extract nor four fractions were more effective than indomethacin. Different types of glycosides found in the genus Phlomis could be responsible for observed effects. Variations in antiinflammatory and analgesic effects of different fractions of this plant might be attributed to the fact that different fractions of P. anisodonta contain active compounds in variable ratios and activities. A comprehensive analysis for determination and quantification of these compounds is required).

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