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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 2  |  Page No.: 166 - 170

Anti-ulcerogenic Screening of Cichorium intybus L. Leaf in Indomethacin Treated Rats

Rifat-uz-Zaman, Muhammad Shoaib Akhtar and Muhammad Shafiq Khan    

Abstract: Although introduction of modern drugs to the classic anti-ulcer therapy has been revolutionized the treatment of peptic ulcer but the complete cure of the disease has yet to be discovered. In an effort to explore indigenous medicinal plants the powdered leaves of Cichorium intybus (CI) and its extracts i.e., aqueous, ethanol, were investigated for their anti-secretary and anti-ulcer activities in the albino rats (Sprague-Dawley, weighing 180-220 g) with gastric ulcer induced by indomethacin (25 mg kg-1, subcutaneous). The treatment of CI attenuated the indomethacin-induced changes in gastric juice volume, pH, acid-output and ulcer index in a dose-dependent manner. The aqueous (CI-Aq) and ethanol (CI-E) extracts (equivalent to 2.0 g kg-1 of body weight) of the powder also protected the rats against gastric effects induced by indomethacin. CI and its extracts showed significant acid buffering in vitro activities. The findings indicate that CI and its extracts possess active principle(s) that protect the gastric mucosa against indomethacin-induced gastric changes, possibly due to its antioxidant effect that inhibits lipid peroxidation.

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