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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 15 - 19

Influx and Efflux of Glutathione During Continuous Pain Induction in Rat Hepatocytes and Glial Cells

Jalal Pourahmad, Niloofar Rezvani, Mohsen Rezaei and Abolhasan Ahmadiani    

Abstract: In this study we examined the intra and extracellular glutathione levels in both glial cells and hepatocytes of rats during continuous pain induction. Animals were divided in 4 groups; one day, four day and seven day pain groups vs. control group. Results showed that the maximum generation of ROS occurs in four day group of continuous pain induction in both glia and hepatocytes of rats. The intracellular GSH was at highest level in one day pain group due to GSH influx and synthesis as two defensive mechanisms against oxidative stress in both glia and hepatocytes. In hepatocytes, however, by considering the levels of extracellular GSSG in one day pain group, it seems that the enzymatic function of GSSG reductase is also another important defense mechanism in the first group of continuous pain induction. Maximum extra cellular GSSG was in 7 day pain group in both glia and hepatocytes. Results suggest that following continuous pain induction, oxidative stress is the major cause for GSH depletion in both glia and hepatocytes and leads cells to the later consequences including apoptosis.

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