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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 1  |  Page No.: 1 - 4

Effect of Chloroquine and Ascorbic Acid Interaction on the Oxidative Stress Status of Plasmodium berghei Infested Mice

H.O.T. Iyawe, A.O. Onigbinde and O.O. Aina    

Abstract: This study was designed to access the interaction of chloroquine and ascorbic acid in parasite induced oxidative stress, with the aim of ascertaining the relevance of such interaction in the treatment of malaria infection. A total of forty mice comprising of twenty males and twenty females were admitted for this study. Each sex category was divided into four groups of five mice and drugs administered intraperitoneally (ip). The presence of parasitemia in mice induced stress in subjects and elevated significantly (p<0.05) the values of all parameters under consideration except Superoxide dismutase (SOD) activity that decreased (p<0.05) in male and female mice. Chloroquine treatment increased (p<0.05) SOD, Alanine and Aspartate aminotransferases (ALT and AST) respectively in both sexes as against control mice. Combination treatment with chloroquine and ascorbic acid reduced (p<0.05) Malondialdehyde (MDA) concentration in female mice and increased (p<0.05) SOD, AST and ALT compared to control mice. The same treatment increased (p<0.05) the activities of AST and ALT in male mice. Chloroquine used in single or in combination with ascorbic acid in the recommended dosage does not appear toxic to mice. A combination of these drugs shows the potential to reduce significantly parasite induced oxidative stress in female mice.

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