Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2005  |  Volume: 1  |  Issue: 3  |  Page No.: 244 - 248

Pharmacokinetics of Chloramphenicol in Healthy and Water-deprived Goats

E.U. Etuk and P.A. Onyeyili    

Abstract: A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by Chemical assay in normal and water-deprived Sokoto red goats revealed that the plasma drug concentrations were significantly higher in water-deprived goats. Various pharmacokinetic parameters like Area Under the Curve (AUC), half- life of elimination (t½β) were significantly lower whereas the total body clearance (Cl) and elimination rate constant (β) were significantly higher in water-deprived goats as compared to normal goats. The mean resident time of the drug also increased from six to nine hours after water deprivation. The higher mean plasma concentration of the drug after water deprivation obtained in the study may indicate the need to reduce the dose of this drug in dehydrated patients to avoid dose-dependent toxicity.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility