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International Journal of Osteoporosis and Metabolic Disorders
Year: 2011  |  Volume: 4  |  Issue: 1  |  Page No.: 26 - 36

Potentox Reduces Biochemical and Inflammatory Response in Osteomyelitis Infection

V.K. Dwivedi, A. Soni, A. Payasi, A. Ahmad, Shambhu P. Singh and M. Chaudhary    

Abstract: The aim of present study was to evaluate the effect of levofloxacin and potentox drugs in osteomyelitis -induced rat model. Staphylococcus aureus 100 μL (1x106 CFU mL-1) was inoculated into the proximal metaphysis of the tibia for induction of osteomyelitis. Body weight and temperature of osteomyelitis-induced rats were monitored every 4th day for three weeks before and after treatment with levofloxacin and potentox. Levofloxacin and potentox were given to animals by intravenously for 21 days. To determine the biochemical parameters (Protein, CRP, Na, Phosphorus, Calcium levels), hepatic enzymes as well as renal function test along with cytokines and malondialdehyde (MDA), myeloperoxidase (MPO) levels in the serum of osteomyelitis-induced untreated and treated groups. Our results showed that the levels of biochemical parameters as well as renal function test along with malondialdehyde, myeloperoxidase levels were significantly altered in the untreated group as compared to levofloxacin and potentox treated groups. When levofloxacin treated group was compared to potentox-treated group, the renal function test and levels of biochemical parameters along with malondialdehyde, myeloperoxidase levels and cytokines were significantly improved in the serum of potentox-treated group. The hepatic enzyme activity was found to be higher in levofloxacin treated group in comparison to potentox-treated group. These study concluded that potentox act as an antioxidant by improving free radical mediated damage and prevents osteomyelitis infection and hepatoxicity in comparison to levofloxacin, caused by Staphylococcus aureus microorganism.

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