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International Journal of Osteoporosis and Metabolic Disorders

Year: 2008  |  Volume: 1  |  Issue: 1  |  Page No.: 8 - 15

Normative Values of Vitamin D Among Iranian Population: A Population Based Study

K. Moradzadeh, B. Larijani, A.A. Keshtkar, A. Hossein-Nezhad, R. Rajabian, I. Nabipour, G.H. Omrani, A. Bahrami, M.M. Gooya and A. Delavari


There is no agreement about normal level of vitamin D and its deficiency stages. For finding normative value of Vitamin D and evaluating the state of vitamin D level in Iranian population we revised the data that was collected in Iranian national Multi-center Osteoporosis Study (IMOS). We chose 5 cities with different climates; individuals were selected by random cluster sampling. Healthy people aged 20-69 were entered into the study and serum vitamin D and PTH levels were measured. We stratified subjects based on their vitamin D levels in 7 groups and compared mean PTH levels of adjacent groups. We evaluated 5329 blood samples for vitamin D and PTH and found three steps of PTH elevation with decreasing vitamin D levels for women (40, 25 and 12 nmol L-1) and two (35 and 25 nmol L-1) for men. We use these values as cutoff levels for definition of normal, mild, moderate and severe vitamin D deficiency states. Based on these cutoffs, prevalence of all stages of vitamin D deficiency was unexpectedly high in all cities. Vitamin D deficiency state was seen in 75.1% of women and 72.1% of men. The high prevalence of vitamin D deficiency in Iran is similar to the results of other studies in Middle East area and indicates a need for a careful search for a determination of cause and need for regular fortification program.

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