Effects of Aqueous Plant Extract Mixtures in Combination with Honey on Wound Healing in Rats: an Animal Model
Wound healing activities of plant extract mixtures in combination with honey was studied on cutaneous excision wounds in rats. Three groups of male Sprague Dawley rats were used and all animals were experimentally wounded in the posterior neck area. Pure un-boiled honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with honey in combination with 5% plant extract mixtures, and honey in combination with 10% plant extract mixtures was applied topically to wounds of Group 3 animals. The effects of vehicles on the rate of wound healing were assessed. Wounds treated with honey in combination with 10% plant extract mixtures were significantly (p<0.05) accelerated wound healing compared to wounds treated by honey alone. These results strongly document the beneficial effects of 10% plant extract mixtures for the acceleration of wound healing process.