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International Journal of Molecular Medicine and Advance Sciences

Year: 2006  |  Volume: 2  |  Issue: 2  |  Page No.: 231 - 235

Acceleration of Wound Healing by Aqueous Extract of Allium sativum in Combination with Honey on Cutaneous Wound Healing in Rats

K. Sidik, A.A. Mahmood and I. Salmah

Abstract

The aqueous extract of garlic (Allium sativum) in combination with honey was evaluated for wound healing activity in rats. Three groups of male Sprague dawley rats each consist of 6 animals. Rats were experimentally wounded in the posterior neck area. A thin layer of pure unboiled honey was applied topically to wounds of Group 1 animals. A. sativum L. in combination with honey was applied topically to wounds of Group 2 rats and a thin layer of solcoseryl - jelly was applied topically to wounds of Group 3 animals. The effects of these topical applicants on the rate of wound infections and on the rate of wound healing were assessed. Wounds of all animals showed clean and remain sterile throughout the experiment until complete healing. Wounds treated with garlic extract in combination with honey significantly accelerate wound healing compared to wounds treated with honey alone. In addition, wounds treated with solcoseryl-jelly also significantly accelerates wound healing compared to wounds treated with honey alone. These results strongly document the beneficial effects of garlic extract in combination with honey for the acceleration of wound healing process and the rates of wounds sterility.

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