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International Journal of Molecular Medicine and Advance Sciences

Year: 2005  |  Volume: 1  |  Issue: 1  |  Page No.: 29 - 33

Effects of Trigonella foenum graecum Seed Extract in Combination with Honey on Experimental Wound Healing in Rats

M.R. Mustafa, A.A. Mahmood and I. Salmah


Trignella foenum graecum (fenugreek) is a traditionally used to treat disorders such as diabetes, high cholesterol, wounds, inflammationand gastrointestinal ailments. We evaluated the wound healing activities of fenugreek seeds on cutaneous excision wounds in rats. Three groups of male Sprague Dawley rats each consist of 6 animals. Rats were placed individually in cages and all animals were experimentally wounded in the posterior neck area. Pure un-boiled honey was applied topically to wounds of Group 1 animals. Wounds of Group 2 rats were treated with honey in combination with fenugreek seed extract, solcoseryl jelly were applied topically to wounds of Group 3 animals as reference. The effects of vehicles on the rate of wound infections and on the rate of wound healing were assessed in whole rats. Wounds of all groups of animals showed clean and remain sterile throughout the experiment. Wounds treated with honey in combination with fenugreek seed or wounds treated with solcoseryl jelly were significantly (p<0.05) accelerates wound healing compared to wounds treated with honey alone. These results strongly document the beneficial effects of fenugreek seed extract for the acceleration of wound healing process and the rates of wounds sterility.