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International Journal of Molecular Medicine and Advance Sciences

Year: 2005  |  Volume: 1  |  Issue: 3  |  Page No.: 225 - 229

Anti-ulcer and Gastro Protective Effects of Honey in Combination with Trigonella foenum graecum Seeds Extract on Experimental Gastric Ulcer in Rats

A.A. Mahmood, K. Sidik and I. Salmah


The gastric protective effect of honey in combination with extract of fenugreek seeds was investigated in rats against ethanol-induced gastric damage. Macroscopically, oral administration of honey alone or honey in combination with seed extracts or with cimeidine induced a significantly decrease (p<0.05) in gastric lesions. Histological studies revealed that honey in combination with aqueous seeds extract was significantly more effective than honey alone or honey in combination with alcoholic extract in preventing gastric lesions formation. These observations showed that fenugreek aqueous seed extracts posse`s anti-ulcer potential.