Abstract: Background and Objective: One of the several side effects of cancer treatment remains cytotoxicity. The curative effect of aqueous zest extract of Citrus paradisi on cisplatin-induced testicular degeneration was studied. Materials and Methods: Sixteen male Wistar rats (10-12 weeks old) weighing 237-276 g were divided into four groups. The first group of rats served as control and were treated orally with 2.5 mL kg^–1 b.wt day^–1, group B rats treated with single dose of 10 mg kg^–1 b.wt., group C and D rats were treated with a single dose of 10 mg kg^–1 b.wt. of cisplatin and then treated orally with 10 and 40 mg kg^–1 b.wt. of aqueous zest extract of Citrus paradisi for 8 weeks. Results: Results showed a significant (p<0.05) decrease in testis weight, testis volume, sperm count, sperm motility and normal sperm morphology (p<0.01). Also, observed was marked degeneration and atrophied tubules with absence of late stage germ cells evidenced by significant reduction in tubular diameter (p>0.01), perimeter (p>0.01), length (p>0.001) and width (p>0.05) in germinal epithelia height (p>0.05), cross-sectional area, number of profiles per unit area and numerical density, PAS-positive materials and Ki67 cells of seminiferous tubules of the rats treated with cisplatin alone. Interestingly, all these parameters were attenuated in the groups that were post-treated with the extract. Conclusion: Based on these evidenced it was concluded that aqueous zest extract of Citrus paradisi have curative roles in the abatement of cisplatin-induced testicular toxicity in Wistar rats.