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International Journal of Cancer Research
Year: 2014  |  Volume: 10  |  Issue: 1  |  Page No.: 37 - 45

Role of Serum Osteopontin Level as a Diagnostic Biomarker for Early Hepatocellular Carcinoma

Mohamed Abdel-Hamid, Doha El-Sayed Ellakwa and Nesreen Nabil Omar    

Abstract: Osteopontin (OPN) was shown to play an important role in the pathogenesis of various inflammatory and fibrotic processes. Recently osteopontin has attracted attention as a promising biomarker for hepatocellular carcinoma (HCC) particularly in patients with low alpha-fetoprotein (AFP) levels. However, the significance of OPN in the early stage hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) remains unclear and is therefore evaluated in this study. Serum AFP and OPN levels were detected by ELISA in 29 patients with hepatocellular carcinoma HCC, in 29 patients with chronic hepatitis C virus (HCV) and in 30 healthy subjects. The diagnostic accuracy of each candidate marker was evaluated using Receiver-Operating Characteristic (ROC) curve analysis, reporting the Area Under the Curve (AUC) and its 95% Confidence Interval (CI). The mean serum OPN level in HCC patients (67.8 ng mL-1) wasn’t significantly different from HCV patients (71.7 ng mL-1) while both were significantly higher than control group (11.6 ng mL-1) (p<0.001). When HCC patients were compared to HCV patients, AUC for OPN and AFP were 0.46 and 0.68, respectively. Based on the ROC analysis, there were no satisfactory cut-off values for OPN that would best distinguish HCC from the non HCC patients. Osteoponti isn’t a useful diagnostic marker for HCC. The current study recommended further search to find more specific biomarker for diagnosing HCC patients with low AFP.

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