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International Journal of Cancer Research
Year: 2013  |  Volume: 9  |  Issue: 1  |  Page No.: 24 - 35

Cortactin and EGFR Proteins Expression in Egyptian Patients with Non-small Cell Lung Carcinoma

A.I. Fawzy, M.F. Gayyed and N.R. Tawfik    

Abstract: Cortactin is an important prognostic biomarker in several malignancies but its role in Non-small Cell Lung Carcinoma (NSCLC) is still poorly defined. Cortactin and Epidermal Growth Factor (EGFR) are involved in tumor cell motility, invasion and metastasis. The present study was designed to investigate the correlation between cortactin and EGFR expression and their relationship to clinicopathological parameters in surgically resected (stage I-III) NSCLC. Tumor tissue sections from 55 surgically resected NSCLC were evaluated for cortactin and EGFR proteins expression by immunohistochemistry. Cortactin protein expression was detected in 52.7% of NSCLC patients and was significantly associated with the degree of differentiation (p = 0.023), pathological lymph node metastasis (p = 0.005) and pathological tumor stage (p = 0.016). EGFR protein expression was observed in 58.2% of NSCLC, more frequently in Squamous Cell Carcinoma (SCC) than non-SCC (78.3% versus 43.7%, p = 0.042). A significantly positive relationship was detected between cortactin and EGFR proteins expression in NSCLC under investigation (p = 0.004). A statistically significant association was observed between cortactin and EGFR expression in NSCLC patients. Cortactin expression is significantly associated with clinicopathological parameters of more advanced disease and could serve as a prognostic biomarker in NSCLC.

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