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International Journal of Cancer Research
Year: 2011  |  Volume: 7  |  Issue: 1  |  Page No.: 8 - 24

Analysia of Her2/neu Overexpression and Amplification in Urothelial Carcinoma of the Bladder Associated with Cox-2 overexpression

Hanan Mohamed Abd ElMoneim, Heba Mohamed Tawfik, Yaser Makram El Sherbiny and Ehab Rifat Tawfiek    

Abstract: This study assessed 110 urothelial carcinomas to determine frequency of Her2/neu overexpression in relation with gene amplification and association between Her2/neu and Cox-2 status and clinicopathologic features. Paraffin-embedded tissues of transurethral resection or cystectomy were evaluated by immunohistochemistry, using antibodies against Her2/neu and Cox-2. All samples with Her2/neu overexpression were evaluated by Florescent in situ Hybridization. It was noticed that overexpression of Her2/neu was seen in 52 patients (47.3%). Her2/neu expression was positive in 19 (46.3%) of 41 squamous cell carcinoma and in 33 (47.8%) of 69 transitional cell carcinoma. Her2/neu overexpression in high grade tumors was statistically significant when compared with low grade (p<0.01). Her2/neu gene amplification was found in 11.5% (6 of 52) of high grade transitional cell carcinoma with muscle invasion of highly expressing Her2/neu protein. Expression of Cox-2 was observed in 58 (52.7%) of the patients. Cox-2 was expressed in 34 (49.3%) of transitional cell carcinoma and in 24 (58%) of squamous cell carcinoma. Cox-2 expression was significantly positive in high grade bladder transitional cell carcinoma than in low grade (p<0.05). Also, there was a significant difference in Cox-2 expression level between superficial and invasive tumors (p<0.05). There is a significant correlation between Her2/neu protein expression and Cox-2.

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