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International Journal of Cancer Research
Year: 2011  |  Volume: 7  |  Issue: 2  |  Page No.: 125 - 134

The Role of Phaseolus vulgaris in DMBA-Induced Sprague-Dawley Rat Mammary Carcinomas

P.C. Pereira, A.F. Vicente, M.F. Mesquita and A.S. Cabrita    

Abstract: The present study intended to study the influence of Phaseolus vulgaris beans in mammary carcinogenesis especially considering the main malignancy indicators through a histopathology study. A total of 72 female rats 50 days old were divided in three groups and hold in constant conditions temperature, light and humidity. Group B and C received 20 mg of 7, 12 dimethyl benzanthracene by gavages. All the animals were fed with the same standard food, group C were supplemented with Phaseolus vulgaris beans. The study had last for 150 days. Tumors in group C animals had lower pattern grades and lower mitotic counts despite the higher weight gain in this group. These results suggest a protective role of bean consumption in mammary carcinogenesis possibly due to fiber and oligossacharides content, especially present in Phaseolus vulgaris from “padrão tarrestre” species.

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