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International Journal of Cancer Research
Year: 2010  |  Volume: 6  |  Issue: 2  |  Page No.: 89 - 94

The Association Between Epstein-Barr Virus with Nasopharyngeal Carcinoma in Patients from Southwestern Region of Iran

S. Nikakhlagh, F. Rahim, A. Khodadadi and N. Saki    

Abstract: The aimed to evaluate the plasma level of Viral Capsid Antigen (VCA)-IgA and IgG in family members of Nasopharyngeal Carcinoma (NPC) patient in comparison to healthy controls in Southwestern of Iran. Total 60 NPC patients were compared with 60 sex, age and ethnically matched healthy controls. The obtained serum samples participants were tested for VCA-IgA, VCA-IgG, Early Antigen (EA), IgG, EBNA-IgG by ELIZA. There was no significant difference in all EBV antibodies between patients and control groups (p>0.05). The serological of three IgG antibody meant that 66.6% of two groups had the past infection; of NPC families 6.6% and from controls 1.6% were susceptible to infection with EBV. 3.3% in members of NPC families had reactivation infection. The sex of the patients in case group had positive correlation with VCA-IgA, EBNA-IgG, EA-IgG and negative correlation with VCA-IgG. The age of the patients also showed positive correlation with EBNA-IgG, EA-IgG, VCA-IgG and negative correlation with VCA-IgA. None of the EBV antibodies had significant correlation with age and sex of the patients. Because of no statistical difference between VCA-IgA mean titr from members of NPC families and controls, there is the not higher risk for members of NPC families to controls for NPC. The cause that had positive VCA-IgA also had positive EBNA-IgG and VCA-IgG. Anti-EBV antibodies can be used as diagnostic markers of NPC in Southwestern region of Iran. The combined use of two or more markers marginally improved the discriminating power but that has to take into consideration the higher costs.

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