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International Journal of Cancer Research

Year: 2010  |  Volume: 6  |  Issue: 1  |  Page No.: 27 - 34

Anti-Cancer Effect of Indirubin-3'-Monoxime for Human Laryngeal Carcinoma

K. Paulkumar, R. Arunachalam, R. Kameswaran, R. Ramanibai and G. Annadurai


The present investigation made in documenting the in vitro anti-proliferative activity of indirubin-3’-monoxime on human epithelial larynx cell line (Hep-2 cells). The Indirubin propensity for anti-proliferative effects was studied and its mechanism of action was documented using the techniques Trypan blue staining, MTT assay and propidium iodide staining. We observed a dose dependent cell death on treatment with indirubin-3-monoxime. On the basis of results, we concluded, indirubin-3’-monoxime inhibits the proliferation of Human laryngeal cancer cells (Hep-2).

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