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International Journal of Cancer Research
Year: 2010  |  Volume: 6  |  Issue: 1  |  Page No.: 19 - 26

Detection of Novel Genomic Polymorphism in Acute Lymphoblastic Leukemia by Random Amplified Polymorphic DNA Analysis

Mohammed A. Ibrahim, Noha Saleh, Esmael Archoukieh, Haithum W. Al-Obaide, Mohannad M. Al-Obaidi and Harun M. Said    

Abstract: Molecular genetic studies suggested that genetic instabilities of genomic DNA are implicated in the pathogenesis of cancers. In this study the molecular genomic polymorphism of acute lymphoblastic leukemia was analyzed by 23 arbitrary primers of decamer oligonucleotides to investigate the genetic correlation by cluster tree analysis. Ten primers were able to amplify genomic DNA of leukemia patients, but varied in their ability to detect genomic DNA instability. One of amplifying primers showed novel pattern of amplified DNA fragments. It amplified DNA fragment (3.162 kbp) in normal individuals but was absent in 77.8% of patients, whereas other amplified DNA fragment (0.98 kbp) was absent in normal individuals but it was present in 55.6% of patients. Moreover, dissimilarity matrix analysis of amplified DNA fragments provided genetic relatedness among genomic DNA of patients.

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