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International Journal of Cancer Research
Year: 2010  |  Volume: 6  |  Issue: 4  |  Page No.: 188 - 201

Perspective of DNA Methylation in Cancer Research

Mohammed A. Ibrahim    

Abstract: DNA methylation is one of three epigenetic mechanisms which has seen increasing interest among cancer researchers, as changes in DNA methylation have emerged as one of the most consistent molecular aberrations in various neoplasms. Aberration of DNA methylation have been identified in the global genomic DNA (hyper or hypo methylation) or within CpG islands in promoter regions of tumor suppressor genes. Several types of bacteria which cause chronic infections are associated with cancer development and chronic infection of Helicobacter pylori might give rise to changes in pattern of DNA methylation. Recent discoveries are giving evidence in the involvement of aberration in DNA methylation in conferring resistance to antitumor agents, and efforts of molecular biologists are directed to overcome this problem by introducing new epigenomic drugs which reform DNA methylation, and help in tumor therapy. Another interesting prospective of current research in DNA methylation is the possibility of development molecular markers for early detection of tumors. The objectives of this article are to review various recent progress of DNA methylation in cancer research.

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