Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Cancer Research
Year: 2009  |  Volume: 5  |  Issue: 3  |  Page No.: 95 - 104

Clove (Syzygium aromaticum) Extract Potentiates Gemcitabine Cytotoxic Effect on Human Cervical Cancer Cell Line

A. Hussain, S. Sasidharan, T. Ahmed, M. Ahmed and C. Sharma    

Abstract: Cervical cancer is the second most common carcinoma in the world among women and is highly chemoresistant and radio resistant, often resulting in local treatment failure. For locally advanced disease, radiation is combined with low-dose chemotherapy; however, this modality often leads to severe toxicity. Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary agents have become not only important potential chemopreventive, but also therapeutic agents when combined with chemotherapy or radiotherapy. In this study, we observed that gemcitabine was highly cytotoxic to both cancer and normal cells while clove extract (0.7-8 mg mL-1) was found to be comparatively more cytotoxic towards cancer cells. Notably, combination of low dose gemcitabine and ethanolic clove extract (2 and 3 mg mL-1) had more pronounced cytotoxic effect on cancer cells than single modalities. It is noteworthy that use of clove extract increased the efficacy of gemcitabine and importantly, it was found to be minimally toxic to normal cells. Together, these results suggest a novel mechanism may be involved in the synergistic effect of this combination.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility