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International Journal of Cancer Research
Year: 2009  |  Volume: 5  |  Issue: 2  |  Page No.: 44 - 52

Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart

L.C. Saalu, G.O. Ajayi, A.A. Adeneye, I.O. Imosemi and A.A. Osinubi    

Abstract: In the present study, we examined the ameliorating effect of the 100% ethanol extract of Citrus paradisi (grapefruit) seed (GSE) on survival of doxorubicin treated rats and on DOX- induced cardiomyopathy. Whereas only 20% of the rats treated with DOX (20 mg kg-1 body weight intraperitoneally) survived at the end of 14 days, almost all the DOX-treated rats survived when GSE (20 mg kg-1 body weight) was administered by gastric gavage. In the second experiment, GSE (20 mg kg-1 body weight) was administered daily by gavage for 14 consecutive days before a cumulative single dose of DOX (20 mg kg-1 body weight, intraperitoneally) was given. DOX induced marked biochemical alterations characteristic of cardiac toxicity. There was enhanced lipid peroxidation measured as malondialdehyde (MDA). The anthracycline antibiotic drug reduced the cardiac enzymatic activities of superoxide dismutase (SOD), glutathione S transferase (GST) and catalase (CAT). Besides, it reduced significantly the reduced glutathione (GSH) level; prior administration of grapefruit seed extract ahead of doxorubicin challenge ameliorated all these biochemical markers. Taken together, one could conclude that grapefruit seed extract has a protective role in the abatement of doxorubicin-induced cardiac toxicity that resides, at least in part, on its anti-radical effects.

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