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International Journal of Cancer Research
Year: 2007  |  Volume: 3  |  Issue: 4  |  Page No.: 174 - 179

DEN-Induced Cancer and its Alleviation by Anisomeles malabarica (L.) R.Br. Ethanolic Leaf Extract in Male Albino Mice

R. Jeyachandran, A. Mahesh and L. Cindrella    

Abstract: Anisomeles malabarica (L.) R. Br. is a traditional medicinal plant of the Labiatae family, distributed throughout India. It has been used in folk medicine for the treatment of cancer and liver disorders. The aim of this work is to study the anticancer effect of crude ethanolic leaf extract of Anisomeles malabarica. Its anticancer activity was evaluated on Diethylnitrosamine (DEN) in mice. The assessment of anticancer activity was evaluated by measuring the activities of total protein, Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Acid Phosphatase (ACP) and Alkaline Phosphatase (ALP). The ethanolic extract at an oral dose of 100 mg kg-1 exhibited a significant (p<0.05) protective effect by reduce liver and serum levels of total protein, GPT, GOT, ACP and ALP as compared to DEN induced mice. These biochemical observations were supplemented by histopathological examination of liver sections. Thus it could be concluded that ethanolic extract of Anisomeles malabarica possesses significant anticancer properties.

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