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International Journal of Cancer Research
Year: 2006  |  Volume: 2  |  Issue: 2  |  Page No.: 102 - 108

Anti-tumor Activity of New Quinoline Derivatives in Human Breast Cancer T47D Cells

Sara Rasoul-Amini, Ali Khalaj, Abbas Shafiee, Mohsen Daneshtalab, Armin Madadkar-Sobhani, Shamileh Fouladdel and Ebrahim Azizi    

Abstract: New cytotoxic quinoline derivatives were designed, synthesized and evaluated in vitro as anti-tumor agents in comparison to available drugs including Adriamycin (ADR), Vincristin (VCR), Etoposide (VP16) and Tamoxifen (TAM). Human breast cancer T47D cells were cultured in RPMI 1640 complete culture medium and exposed for 48 h to different concentrations of newly synthesized quinoline derivatives [SRA-HX-(1-3) and SRA-BQ] and also to ADR, VCR, VP16 and TAM. A dose-dependent decrease in cell proliferation was observed following exposure to almost all synthesized quinolines. The highest cytotoxicity was seen at 1x10-4M concentration of SRA-HX-3 that was near to growth inhibitory effect of ADR (1x10-6M) and significantly (p<0.002) greater than VCR, VP16 and TAM (each at 1x10-6M). The other 3 compounds (1x10-4M) had similar activity to VCR that was less than ADR and significantly (p<0.002) greater than VP16 and TAM. Therefore, new cytotoxic quinolines are potentially good candidates for further investigation as anti-tumor compounds.

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